The link between Cdc42 and GSK3beta
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In migrating astrocytes GSK3beta exists in complex with Par6 and PKCz. Cdc42 activates Par6-PKCz complex, leading to phosphorylation and dissociation of GSK3beta from Par6-PKCz complex (Etienne-Manneville and Hall 2003). Phosphorylation of GSK3beta inhibits its catalitic activity (reviewed in: Harwood 2001).