The link between GSK3beta and APC
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GSK3beta phosphorylates APC and decreases its ability to stabilise microtubules (Zumbrunn et al. 2001). In the migrating astrocytes GSK3beta regulates APC functions to control the cell polarity (Etienne-Manneville and Hall 2003) and in DRG neurons the control of APC by GSK3beta is important in the regulation of axon morphology (Zhou et al. 2004).