The link between GSK3beta and APC

GSK3beta phosphorylates APC and decreases its ability to stabilise microtubules (Zumbrunn et al. 2001). In the migrating astrocytes GSK3beta regulates APC functions to control the cell polarity (Etienne-Manneville and Hall 2003) and in DRG neurons the control of APC by GSK3beta is important in the regulation of axon morphology (Zhou et al. 2004).