The link between TrkA and PI3K

NGF induces activation of phosphatidylinositol 3 - kinase (PI3K) and its association with NGF receptor (TrkA) (Soltoff, Rabin et al. 1992). Sustained activation of PI3K is necessary for neurite development (Kimura, Hattori et al. 1994) while constitutively active form of this enzyme is sufficient to induce neurite formation (Kobayashi, Nagata et al. 1997).